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I don’t know that I’ve ever seen a modern plane that can land on water that carried more than a handful of passengers.
Largest I know of are some Twin Otters in Canada have floats. 16-20 people, but I’d call them exceptional and a Cessna caravan type is a typical large float plane. https://en.m.wikipedia.org/wiki/De_Havilland_Canada_DHC-6_Twin_Otter
There you go. We’re just not flying the Spruce Goose and I’m guessing for cargo reasons if for no other, you want to be able to land large planes.