Seems pretty tame compared to various other answers, but keeping people under anesthesia longer than expected during surgery and seeing how it affects things like memory or personality.

Supposedly after an open heart surgery I had gone through over a decade ago, my mother swears my personality changed. Though I can’t remember if that’s true because my memory has felt, in a sense, kinda foggy since then. So I wanna know if it was because I was under for longer than expected or because the surgery itself.

Remove every unhealthy person and/or gene modify existing ones to eliminate every allergy orbodily defect caused by gene defect.

Also gene modify so that theres no mental detorioration and humans die just because they are old and the nody can’t keep up with maintenance.

I heard there’s a guy called Luigi with a cool idea.

Just wipe out ALL mosquitoes, and then measure what the actual influence is on the food-web for other animals and plants.

I love the story of the father who raised his son on Klingon until it became too awkward for modern usage.

Thought that would be a fun experiment on my child. Don’t know much Klingon though.

Trolling against some lemmy mods? (surely one of the most hazardous things to to)

Throwing somebody straight into lava in a volcano. Would be interesting to see what happens.

I’d like to see if we can build hybrid computer systems using cultured animal tissue (like Cephalopod or maybe GMO human / Cephalopod), basically grown onto an array of tiny wires. Push sensory information through the tiny wires and see if the lump of cells can learn. If it does, put it in a Eva. Or a butler robot. Or a robot vaccuum.

Idk. Its an idea for a scifi novel I’ve had. Some company does this and what people don’t realize is the supposedly autonomous systems making their lives easier are fully conscious but live tortured existences. It would get more and more lovecraftian as the cephalopod hybrids some how take over (I was thinking maybe cancer? or networked mind) and start chopping everyone to bits. Maybe they try and eat them but they have no mouth, like how an octopus arm when detach will hunt and try to feed a non-existent mouth.

Making a lot of clones of myself, raising them all differently, and seeing how many of them turn out in the same way as me.

Here’s a very unethical linguistics experiment that I think would be interesting:

Raising a group of children completely isolated from any language, spoken or otherwise. They would not be fully isolated from people, but those people would not be able to communicate with each other in the vicinity of the children (no speaking, no gestures, etc.) Of course, to isolate them from language would mean strictly controlling their lives (very unethical). Could they communicate with each other, and maybe even develop a language?

Hypothesis: Conservatives will refuse to believe contradicting facts regardless of punishment.

Experiment: Use increasingly painful stimulus for negative reinforcement when subjects espouse harmful views, ie racism.

Take ten or twenty thousand children, take over a fairly large portion of a midwestern state, build a large and complete environment for them to live in including towns, museums, theme parks etc. and raise them as normal Americans but absolutely 100% avoid introducing them to the concept of religion until they’re 25.

I really want someone to just really start messing around with the human genome, see the limits of gene expression. Let’s add horns, let’s add tusks, let’s add tails, and wings, and carapaces, and antennae, and claws, let’s just see what happens. Human evolution has gotten so tired and trite; let’s add some spice.

How many billionaires need to be publicly executed to fix the usa political system.

I find those rats with the NOVA1 gene fascinating. I wonder what would happen if we downright tried to give rats human-level intelligence? They are more empathetic than humans I hear, they would make the perfect replacement for our species!

And another thing I would like to try, is to find a really big person, and see how far they can swallow me feet-first, before they run into problems, or one of us is injured.